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By Charles Wood Ph.D. (auth.), C. Meyers (eds.)

AIDS-associated viral oncology is an important healthcare challenge. because the id of human immunodeficiency virus (HIV)-associated got immune sickness syndrome (AIDS), the position of viruses in human cancers has develop into acutely obvious over the last two decades. the knowledge and therapy of AIDS-associated cancers has develop into a huge predicament between healthcare companies. Human cancers that have been as soon as infrequent within the inhabitants have now develop into universal in the HIV contaminated inhabitants.

Experts proportion their collective wisdom and look at the scientific and organic points, together with viruses good demonstrated of their roles, in addition to rising new viruses. This quantity may be a source for either contributors of the clinical and healthcare neighborhood and lively researchers during this field.

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"Human immunodeficiency virus (HIV) - linked got immune sickness syndrome (AIDS) areas participants at elevated danger for virally mediated cancers. this article addresses the scientific and organic elements of this subject. individual investigators within the box current a entire assessment with relevance to laboratory scientists and practising clinicians."

Steven T. Rosen, M.D.

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Antineoplastic treatment of AIDS-associated HL has many problems considering the underlying immunodeficiency caused by HIV itself that is further compromised by additional chemotherapy. 110 Gerard and colleagues129 in a retrospective study over 15 years estimated the 2-year survival probability was 45% in the pre-HAART period, and 62% in the post-HAART period. 131 Chemotherapy and HAART Several prospective trials to date have now been done using antiretrovirals concomitantly with different chemotherapy regimens.

15–17 2. AIDS Malignancies 23 ROLE OF EBV IN DIAGNOSIS OF PCNSL EBV studies have been largely used as one of the least invasive ways to diagnose AIDS PCNSL. Specifically, using polymerase chain reaction (PCR) to detect EBV DNA in the CSF is useful for diagnosing AIDS-associated CNS lymphoma. 18–21 Brink and colleagues22 demonstrated in a prospective study that the presence of EBV DNA in CSF was strongly linked with a diagnosis of CNS lymphoma, even when the clinical and radiological features of this disease were not present.

159–161 HHV-8 PATHOGENESIS IN KS Multiple factors contribute to the development of KS. 162,163 Since the discovery of HHV-8, there have been a large number of studies evaluating its underlying role in KS. 165 found that the risk of developing disease increased with HHV-8 antibody titers. 166–169 HHV-8 has been shown to have certain genes to be homologous to cyclin D1 and G-protein coupled receptors, which are known to contribute to oncogenesis. 150,170,171 HIV PATHOGENESIS IN KS The HIV virus itself may be an oncogene in KS development.

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