By Y. Becker (auth.), Yechiel Becker, Julia Hadar (eds.)
Research on antiviral medicines and their mode of motion in contaminated cells. in animals and in guy. has ended in a greater knowing of the molecular professional cesses interested by virus replication. Screeninq of enormous numbers of average and semisynthetic compounds ended in the characterization of yes sub stances that had a restricted potency as antiviral druqs. a couple of chemically synthesized compounds have been additionally chanced on to be potent as antiviral brokers within the chemotherapy of human virus ailments. an enormous trouble within the enhance ment of powerful antiviral brokers has been the inability of selectivity. and toxicity for uninfected cells. of substances that successfully inhibited virus replication in vitro. additional knowing of the molecular procedures of virus replication in contaminated cells has ended in the improvement of latest antivirals directed at virus-coded enzymes or proteins. fresh experiences on antivirals which are activated by way of the herpes simplex virus kind l-coded thy midine kinase from a prod rug to an antiviral drug have opened new instructions within the improvement of powerful antiviral medications. the current booklet bargains with a couple of antiviral medicines powerful opposed to herpes simplex viruses and gives a few perception into the molecular features of virus replication. It additionally throws mild at the new techniques to the advance of antiviral medications. The molecular foundation of the antiviral job of latest and identified medications and their attainable use in chemotherapy of viral affliction are provided during this book.
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Extra info for Antiviral Drugs and Interferon: The Molecular Basis of Their Activity
35 CONCLUSIONS 1. 2. 3. 4. AldUrd, and IdUrd are phosphorylated by the herpes thymidine kinase to AldUDP and IdUDP and then presumably by cellular enzymes to AldUTP and IdUTP respectively. Both are incorporated into herpes progeny DNA by herpes DNA polymerase in place of thymidine. Incorporation into DNA results in: a) formation with AldUrd of phosphoramidate bonds in DNA was well as single- and double-stranded breaks. IdUrd produces normal phosphodiester bonds in DNA with no single- or double stranded breaks.
Contro17 0------0, AIdUrd. The direction of sedimentation is from the right to the left. " 24 The reason for these breaks is still unclear. It was originally thought that they were the result of the fragility of the phosphoramidate bond. It now seems unlikely that either the presence of the phosphoramidate alone or the presence of iodine alone at the 5 position is responsible for the breaks. Studies with 5'-amino2',5 '-dideoxythymidine (Otto and Prusoff, unpublished), which also forms a phosphoramidate bond in the DNA, or with IUdR (Figure 4) indicate no increased breakage of the viral DNA (34).
4. 5. 6. 7. s. 9. 10. 11. 12. 13 • 14. 15. 16. 17. 18. 19. H. Biochim. Biophys. :295-296, 1959. , Jr. Proc. Soc. Exp. BioI. Med. :142-145, 1961. H. and Goz, B. In: Antineoplastic Immunosuppressive Agents Vol. 2 CEds. C. G. Johns) Springer, Berlin, 1975 pp. 272-347. , Marola, E. and Dohlman, C. Arch. Opthalmol. ~:235-239, 1960. Goz, B. H. J. BioI. U:47504756, 1968. Aamodt, L. and Goz, B. Biochem. Pharmacol. ~:2400-2403, 1970. Goz, B. H. Ann. Y. Acad. Sci. 11l:379-389, 1970. Kan-Mitchell, J. H. Biochem.